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30.04.2012 4:20   Vaccinarea nu functioneaza - studiu stiintific  citat 

Un studiu stiintific recent (adresa mai jos) arata ca nu este nici o legatura intre injectare/vaccinare si supravietuire.

Abstract: "Neutralizing antibodies have been thought to be required for protection against acutely cytopathic viruses, such as the neurotropic vesicular stomatitis virus (VSV). Utilizing mice that possess B cells but lack antibodies, we show here that survival upon subcutaneous (s.c.) VSV challenge was independent of neutralizing antibody production or cell-mediated adaptive immunity. However, B cells were absolutely required to provide lymphotoxin (LT) α1β2, which maintained a protective subcapsular sinus (SCS) macrophage phenotype within virus draining lymph nodes (LNs). Macrophages within the SCS of B cell-deficient LNs, or of mice that lack LTα1β2 selectively in B cells, displayed an aberrant phenotype, failed to replicate VSV, and therefore did not produce type I interferons, which were required to prevent fatal VSV invasion of intranodal nerves. Thus, although B cells are essential for survival during VSV infection, their contribution involves the provision of innate differentiation and maintenance signals to macrophages, rather than adaptive immune mechanisms."

Autori: E. Ashley Moseman (1), Matteo Iannacone (1,2,8 ), Lidia Bosurgi (1,3), Elena Tonti (1,2), Nicolas Chevrier (4,5), Alexei Tumanov (6), Yang-Xin Fu (7), Nir Hacohen (4,5), Ulrich H. von Andrian (1,8 )

1.Immune Disease Institute and Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
2.Division of Immunology, Infectious Diseases and Transplantation San Raffaele Scientific Institute, Milan, Italy
3.Vita-Salute San Raffaele University, Milan, Italy
4.Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
5.Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02129, USA
6.Trudeau Institute, Saranac Lake, NY 12983, USA
7.Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
8.Corresponding author

http://www.cell.com/immunity/abstract/S...12)00057-X


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